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selective rorγ antagonist  (MedChemExpress)


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    MedChemExpress selective rorγ antagonist
    SR2211, the inverse agonist of <t>RORγ,</t> attenuated the sweat secretion and Th17 lymphocyte related inflammatory response <t>in</t> <t>hyperhidrosis</t> mice. Mice were administered with vehicle or SR2211 for one week before the induction of hyperhidrosis, as shown in (A) . The number of black dots were calculated (B) . The number of sweat secretory granules were counted (C) and the concentration of acetylcholine in serum was detected by ELISA (D) . Th17 lymphocyte subpopulations in peripheral blood of the mice were compared (E) . The serum levels of IL-17 (F) and IL-6 (G) were measured by ELISA. Western blotting was used to detect the protein expression of IL-17A in the sweat gland of hyperhidrosis mice (H) . GAPDH was used as a loading control and the expressions were normalized to control (I) . The data were presented with mean ± SD. n = 8 for each group. **p < 0.01, ***p < 0.001 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.
    Selective Rorγ Antagonist, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/selective rorγ antagonist/product/MedChemExpress
    Average 93 stars, based on 2 article reviews
    selective rorγ antagonist - by Bioz Stars, 2026-03
    93/100 stars

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    1) Product Images from "Altered Th17/Treg balance and therapeutic targeting of RORγ in primary focal hyperhidrosis"

    Article Title: Altered Th17/Treg balance and therapeutic targeting of RORγ in primary focal hyperhidrosis

    Journal: Frontiers in Immunology

    doi: 10.3389/fimmu.2025.1656632

    SR2211, the inverse agonist of RORγ, attenuated the sweat secretion and Th17 lymphocyte related inflammatory response in hyperhidrosis mice. Mice were administered with vehicle or SR2211 for one week before the induction of hyperhidrosis, as shown in (A) . The number of black dots were calculated (B) . The number of sweat secretory granules were counted (C) and the concentration of acetylcholine in serum was detected by ELISA (D) . Th17 lymphocyte subpopulations in peripheral blood of the mice were compared (E) . The serum levels of IL-17 (F) and IL-6 (G) were measured by ELISA. Western blotting was used to detect the protein expression of IL-17A in the sweat gland of hyperhidrosis mice (H) . GAPDH was used as a loading control and the expressions were normalized to control (I) . The data were presented with mean ± SD. n = 8 for each group. **p < 0.01, ***p < 0.001 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.
    Figure Legend Snippet: SR2211, the inverse agonist of RORγ, attenuated the sweat secretion and Th17 lymphocyte related inflammatory response in hyperhidrosis mice. Mice were administered with vehicle or SR2211 for one week before the induction of hyperhidrosis, as shown in (A) . The number of black dots were calculated (B) . The number of sweat secretory granules were counted (C) and the concentration of acetylcholine in serum was detected by ELISA (D) . Th17 lymphocyte subpopulations in peripheral blood of the mice were compared (E) . The serum levels of IL-17 (F) and IL-6 (G) were measured by ELISA. Western blotting was used to detect the protein expression of IL-17A in the sweat gland of hyperhidrosis mice (H) . GAPDH was used as a loading control and the expressions were normalized to control (I) . The data were presented with mean ± SD. n = 8 for each group. **p < 0.01, ***p < 0.001 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.

    Techniques Used: Concentration Assay, Enzyme-linked Immunosorbent Assay, Western Blot, Expressing, Control



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    selective rorγ antagonist  (MedChemExpress)
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    MedChemExpress selective rorγ antagonist
    SR2211, the inverse agonist of <t>RORγ,</t> attenuated the sweat secretion and Th17 lymphocyte related inflammatory response <t>in</t> <t>hyperhidrosis</t> mice. Mice were administered with vehicle or SR2211 for one week before the induction of hyperhidrosis, as shown in (A) . The number of black dots were calculated (B) . The number of sweat secretory granules were counted (C) and the concentration of acetylcholine in serum was detected by ELISA (D) . Th17 lymphocyte subpopulations in peripheral blood of the mice were compared (E) . The serum levels of IL-17 (F) and IL-6 (G) were measured by ELISA. Western blotting was used to detect the protein expression of IL-17A in the sweat gland of hyperhidrosis mice (H) . GAPDH was used as a loading control and the expressions were normalized to control (I) . The data were presented with mean ± SD. n = 8 for each group. **p < 0.01, ***p < 0.001 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.
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    SR2211, the inverse agonist of <t>RORγ,</t> attenuated the sweat secretion and Th17 lymphocyte related inflammatory response <t>in</t> <t>hyperhidrosis</t> mice. Mice were administered with vehicle or SR2211 for one week before the induction of hyperhidrosis, as shown in (A) . The number of black dots were calculated (B) . The number of sweat secretory granules were counted (C) and the concentration of acetylcholine in serum was detected by ELISA (D) . Th17 lymphocyte subpopulations in peripheral blood of the mice were compared (E) . The serum levels of IL-17 (F) and IL-6 (G) were measured by ELISA. Western blotting was used to detect the protein expression of IL-17A in the sweat gland of hyperhidrosis mice (H) . GAPDH was used as a loading control and the expressions were normalized to control (I) . The data were presented with mean ± SD. n = 8 for each group. **p < 0.01, ***p < 0.001 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.
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    Image Search Results


    SR2211, the inverse agonist of RORγ, attenuated the sweat secretion and Th17 lymphocyte related inflammatory response in hyperhidrosis mice. Mice were administered with vehicle or SR2211 for one week before the induction of hyperhidrosis, as shown in (A) . The number of black dots were calculated (B) . The number of sweat secretory granules were counted (C) and the concentration of acetylcholine in serum was detected by ELISA (D) . Th17 lymphocyte subpopulations in peripheral blood of the mice were compared (E) . The serum levels of IL-17 (F) and IL-6 (G) were measured by ELISA. Western blotting was used to detect the protein expression of IL-17A in the sweat gland of hyperhidrosis mice (H) . GAPDH was used as a loading control and the expressions were normalized to control (I) . The data were presented with mean ± SD. n = 8 for each group. **p < 0.01, ***p < 0.001 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.

    Journal: Frontiers in Immunology

    Article Title: Altered Th17/Treg balance and therapeutic targeting of RORγ in primary focal hyperhidrosis

    doi: 10.3389/fimmu.2025.1656632

    Figure Lengend Snippet: SR2211, the inverse agonist of RORγ, attenuated the sweat secretion and Th17 lymphocyte related inflammatory response in hyperhidrosis mice. Mice were administered with vehicle or SR2211 for one week before the induction of hyperhidrosis, as shown in (A) . The number of black dots were calculated (B) . The number of sweat secretory granules were counted (C) and the concentration of acetylcholine in serum was detected by ELISA (D) . Th17 lymphocyte subpopulations in peripheral blood of the mice were compared (E) . The serum levels of IL-17 (F) and IL-6 (G) were measured by ELISA. Western blotting was used to detect the protein expression of IL-17A in the sweat gland of hyperhidrosis mice (H) . GAPDH was used as a loading control and the expressions were normalized to control (I) . The data were presented with mean ± SD. n = 8 for each group. **p < 0.01, ***p < 0.001 from Brown-Forsythe ANOVA test followed by Dunnett’s T3 multiple comparisons test.

    Article Snippet: To validate the clinical relevance of these findings and evaluate the therapeutic potential of immunomodulation, we established a pilocarpine-induced mouse model of hyperhidrosis and assessed the effects of SR2211, a selective RORγ antagonist (MedChemExpress, Cat# HY-16998, purity 99.67%) with low reported off-target activity against RORα, RORβ, and kinases such as TRK and BRAF.

    Techniques: Concentration Assay, Enzyme-linked Immunosorbent Assay, Western Blot, Expressing, Control